Advantage Treatment Shampoo for Dogs & Puppies kills fleas and ticks on contact to help prevent fleas that may cause redness irritation and itching. Use this shampoo once every 7 days to kill fleas and ticks and clean and condition your dog s coat. To use simply wet your dog s coat for 2-3 minutes with warm water apply the shampoo and massage it into a lather. Be sure to focus on areas where fleas and ticks are most commonly found such as around the ears neck and tail. Allow the shampoo to sit for 5 minutes before rinsing thoroughly. Advantage is a trademark of Elanco or its affiliates.