NCX1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3833-50, ES3833-100

Citations, Manuals and MSDS Available upon request.

Background: In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) concentration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+)-Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004],

Alternate Name: SLC8A1; CNC; NCX1; Sodium/calcium exchanger 1; Na (+)/Ca (2+)-exchange protein 1

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from NCX1 . at AA range: 270-350

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 108kD

Human Gene ID: 6546

Human SWISS Prot NO: P32418

Subcellular Location: Cell membrane; Multi-pass membrane protein.

Research Use Only