mGluR-2/3 (N867) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3430-50, BS3430-100

Sizes: 50µl, 100µl

Swiss-Prot: Q14416/Q14832

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

Background: The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: mGluR-2/3 (N867) polyclonal antibody detects endogenous levels of mGluR-2 and mGluR-3 protein

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of mGluR-2/3 (N867)pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 95 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 3; mGluR3; GRM3; GPRC1C; MGLUR3

Immunogen: Synthetic peptide, corresponding to amino acids 836-886 of Human mGluR-2.

Conjugate: Unconjugated

Modification: Unmodified