Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes.

Product information

CAS Number: 63358-49-6

Molecular Weight: 493.53

Formula: C21H27N5O7S

Chemical Name: (2S,5R,6R)-6-[(2R)-2-[(2R)-2-amino-3-(methylcarbamoyl)propanamido]-2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Smiles: CNC(=O)C[C@@H](N)C(=O)N[C@H](C1C=CC(O)=CC=1)C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C(O)=O)N2C1=O

InChiKey: BHELIUBJHYAEDK-OAIUPTLZSA-N

InChi: InChI=1S/C21H27N5O7S/c1-21(2)15(20(32)33)26-18(31)14(19(26)34-21)25-17(30)13(9-4-6-10(27)7-5-9)24-16(29)11(22)8-12(28)23-3/h4-7,11,13-15,19,27H,8,22H2,1-3H3,(H,23,28)(H,24,29)(H,25,30)(H,32,33)/t11-,13-,14-,15+,19-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 25 mg/mL (50.66 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Aspoxicillin is a semisynthetic penicillin derivativeAspoxicillin induces postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro.

In Vivo:

Aspoxicillin induces PAEs against Staphylococcus aureus Smith of 5.2 h in vivo in a thigh infection model in neutropenic mice.

Products are for research use only. Not for human use.